My purpose is simple: to change the landscape for life. Modern people have a concept of life based on the central dogma, bound to a class of materials, such as  DNA, RNA, and proteins. On the other hand, accumulating evidence suggests that nonliving soft matter can behave in a life-like manner. This finding has led me to rethink the possibility of life free from central-dogma materials.

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Previous studies have shown that, in cellular reaction fields, the directions in which molecules spread are constrained. In other words, there are reaction fields in which components move in one dimension, such as microtubules; in two dimensions, such as lipid rafts; and in three dimensions, such as droplets of bio-macromolecules formed via Liquid-liquid phase separation. The presence of such constraints is crucial for the orchestration of reaction fields. Without constraints, reaction fields can only adopt spherical shapes that minimize interfacial tension, making it impossible for distant reaction fields to coordinate with one another.

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I am trying to conduct four parallel projects that will form the foundation of this discipline. The first is “droplet generation–disappearance studies,” which will enable component-specific generation and disappearance reactions of reaction fields in mixed amino acid solutions. The second is “droplet synthetic biology,” in which multiple enzymes will be simultaneously converted into droplets using my droplet generation–disappearance device, butterfly-shaped nanoparticles (GNB), to drive continuous reactions resembling respiration and photosynthesis, such as redox reactions and carbon assimilation reactions. The third project is the establishment of “interdimensional reaction-field interaction studies”, analysis of interactions between different dimensional reaction fields. The fourth is “droplet dynamics prediction studies,” which will enable computational reconstruction of protein droplets, analysis of complex behaviors such as droplet dynamics and phase transitions, and extraction of physical properties such as interfacial tension and internal energy. Based on the understanding from the above four projects, I have a plan to summarize all of the knowledge in dynamic graph theory, a way of deriving topics and interactions, and show a uniform rule to determine when the reaction fields work in a life-like way. If the rule is true, the assembly of reaction fields composed of different materials- not DNA, RNA, and proteins, but having similar characteristics as life can work in a life-like manner.